Description:

Osler, M.D. William 1849 - 1919 William Osler hand written heart research correspondence between himself and a medical colleague, Sir Leonard Rogers, a founder member of the Royal Society of Tropical Medicine.

Single page autograph note, 7" x 4.5", undated and unsigned but in the hand of William Osler in what appears to be his personal notes on the compiling of research of aneurysm. Toned with a small corner chip, not affecting text. Near fine. This piece is included with the original TLS with annotations from his colleague, Sir Leonard Rogers, 6" x 7.75". Expected folds, else near fine.

An important correspondence in the midst of Osler's profound 1908 research on heart diseases. This set includes a first hand rapport between Osler and Leonard Rogers from the Calcutta Medical College in 1908. Osler had published his initial findings on "Diseases of the arteries Modern Medicine: Its Practice and Theory". Philadelphia: Lea & Febiger, 1908: 429-47", and continued active pursuit to understand all the mechanisms at work. Today, Osler's research is once again coming to the forefront as we learn more about disease and the human body.

In 1908, Sir William Osler was the first to suggest that infection might play a role in the parthenogenesis of atherosclerosis. Even though this view was not widely accepted originally, a renewed interest currently abounds regarding the contribution of infection to the parthenogenesis and progression of ischemic heart disease. The current concept of atherosclerosis is based on the model "response to injury" proposed by Ross in 1986, however most of the published material consists of epidemiological studies based on associations between the serology of the respective antibodies and ischemic heart disease or on immunohistochemical evidence of the presence of bacteria or viruses in atherosclerotic lesions. Recently, new evidence originating from controlled clinical trials has emphasized this new paradigm for managing ischemic heart disease.

Knowing the data from the different available studies, one can say that evidence relating infectious agents to the etiology of atherosclerosis does exist. One cannot yet, however, define whether these agents have the capacity to cause atherosclerosis, to promote progression of the lesions, or simply to be innocuous commensals of atherosclerotic plaques.

This fantastic set demonstrates the interactions Osler had with his colleague Sir Leonard Rogers, a founder member of the Royal Society of Tropical Medicine and Hygiene. However scientists throughout the world were all pulling together research on heart disease. Rodgers along with others were all funneling information to Osler to assist with his important research. Rogers TLS follows up on his studies on numerous prominent diseases found in India with emphasis on aneurysm (a form of heart disease) in India. Rodgers was researching prevalence of aneurysm in natives, and commented that Norman Chevers, an English physician, found that "The result of my own experience is that aneurysm is a rare disease in the natives of India, although I saw many cases in Calcutta the largest city". This begs to consider the multitude of factors which can be attributed this variance, whether environmental, life style differences, or even perhaps differences in diet, proximity to diseases or other. Rodgers added a handwritten postscript in which he notes " the evidence of heart diseases here differ widely from European experience, owing to the practical absence of Rheumatic and scarlet fever. I hope to work this out later."

Olser's ANS appears to be thematic in nature maintaining hypothesis and directions to pursue additional research and contains his research notes. He appears to be referencing published research as he references to "see D. Med Woch. 1888", and sorts out information gathered on aneurysm.

A perfect set for the collector of the study of early medical research with Osler's scarce handwritten notes.

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